| Bioactivity | [Ala2] Endothelin-3, human is a linear analog of endothelin-3 (ET-3) where substitution of Ala for Cys residues. TE-3 is a vasoactive peptide, produced by human rhabdomyosarcoma cell lines, whereas it is not expressed by human sarcoma cell lines of non-muscle origin. ET-3 acts as a paracrine factor, since it promotes migration of endothelial cells[1][2]. |
| Name | [Ala2] Endothelin-3, human |
| CAS | 2243207-08-9 |
| Sequence | Cys-Ala-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridge: Cys1-Cys15; Cys3-Cys11) |
| Shortening | CACFTYKDKECVYYCHLDIIW (Disulfide bridge: Cys1-Cys15; Cys3-Cys11) |
| Formula | C120H166N26O32S4 |
| Molar Mass | 2613.02 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Palladini A, et al. Endothelin-3 production by human rhabdomyosarcoma: a possible new marker with a paracrine role. Eur J Cancer. 2006 Mar;42(5):680-7. [2]. Davenport AP, et al. Endothelin. Pharmacol Rev. 2016 Apr;68(2):357-418. |
[Ala2] Endothelin-3, human
CAS: 2243207-08-9 F: C120H166N26O32S4 W: 2613.02
Endothelin-3, human is a linear analog of endothelin-3 (ET-3) where substitution of Ala for Cys residues. TE-3 is a
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